[10/2012]
E.T. Papoutsakis received the 2012 James E. Bailey Award at the 2012 AIChE annual meeting, Pittsburgh, PA. (read more)


[06/2012]
Stefan Gaida won best poster award for "tools and methods development" at the Metabolic Engineering IX Conference (An ECI Conference Series) in Biarritz, France.


[08/08/2011]
2011 ACS Fellow
E. Terry Papoutsakis has been selected as 2011 American Chemical Society (ACS) Fellow.


[1/06/10]
2010 Elmer Gaden Award
E. Terry Papoutsakis and former group member Ryan Senger (Assistant Professor at Virginia Tech) are honored with the 2010 Elmer Gaden Award by Biotechnology Bioengineering and John Wiley Sons, Inc. for their paper: Genome-Scale Model for Clostridium acetobutylicum: Part I. Metabolic Network Resolution and Analysis


[01/06/10]
A genomic-library based discovery of a novel, possibly synthetic, acid-tolerance mechanism in Clostridium acetobutylicum involving non-coding RNAs and ribosomal RNA processing.
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[12/07/09]
Metabolite stress and tolerance in the production of biofuels and chemicals: Gene-expression-based systems analysis of butanol, butyrate and acetate stresses in the anaerobe Clostridia acetobutylicum


Genomics, systems and synthetic biology, and metabolic engineering applied to stem-cell bioengineering and biorefining. The Papoutsakis Group focuses on the study and modification of regulatory networks that control key cellular programs such as stem-cell differentiation and plasticity or prokaryotic sporulation and stationary-phase phenomena. This research contributes to the understanding of cellular processes of both fundamental and industrial interests - such as stem-cell bioengineering or the link between sporulation, solvent production and stress response in solventogenic clostridia for biofuel production and biorefinery applications - and involves interdisciplinary work in the areas of systems biology, metabolic engineering, experimental and computational genomics, stem-cell biology, and hematology. By combining state-of-the-art microarray and genomic analysis techniques with molecular biological tools and cellular physiology, the Papoutsakis Group aims to unravel the exquisitely crafted interplay of cellular processes that allow the exploration of cells for beneficial applications from Regenerative Medicine to Industrial Biotechnology.



The Papoutsakis Research Group is an active, vibrant and collaborative team of educators, students, researchers and scientists. The group is comprised of PhD and other graduate students, postdoctoral fellows, a lab manager, undergraduate and visiting students, occasionally visiting scientists, and Papoutsakis’ administrative coordinator. Our mission is to carry out world-class, forward-looking, genomic-based research in the context of bioengineering, biochemical engineering and more broadly modern biology. Based at the Delaware Biotechnology Institute at the University of Delaware, the Papoutsakis Research Group is dedicated to initiating and supporting the best of front line research and technology within the ever-changing and wide-ranging scope of the molecular life sciences.
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The research facilities for the Group are in laboratories in the Delaware Biotechnology Institute, which is a state-of-the art research facility for modern research in the biological sciences and bioengineering.
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[12/13]
Venkataramanan, K. P., Jones, S. W., McCormick, K. P., Kunjeti, S. G., Ralston, M. T., Meyers, B. C., & Papoutsakis, E. T. (2013). The Clostridium small RNome that responds to stress: the paradigm and importance of toxic metabolite stress in C. acetobutylicum. BMC genomics, 14(1), 849.

[11/13]
Wang Q, Venkataramanan KP, Huang H, Papoutsakis ET and Wu C. “Transcription factors and genetic circuits orchestrating the complex, multilayered response of Clostridium acetobutylicum to butanol and butyrate stress” BMC Systems Biology. 2013, 7:120.

[1/13]
Zingaro, KA, Papoutsakis, ET, 2012. GroESL overexpression imparts Escherichia coli tolerance to i-, n-, and 2-butanol, 1,2,4-butanetriol and ethanol with complex and unpredictable patterns. Metab. Eng.
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[1/13]
Jiang, J, Papoutsakis, ET, 2012. Stem-cell niche based comparative analysis of chemical and nano-mechanical material properties impacting ex vivo expansion and differentiation of hematopoietic and mesenchymal stem cells. Adv. Healthc. Mater.
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[11/12]
Nicolaou, SA, Gaida, SM, Papoutsakis, ET. 2012. Exploring the combinnatorial genomic space in Escherichia coli for ethanol tolerance. Biotechnol. J.
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[11/12]
Al Hinai, M, Fast, AG, Papoutsakis, ET, 2012. Novel system for efficient isolation of Clostridium double-crossover allelic exchange mutants enabling markerless chromosomal gene deletions and DNA integration. Appl. Environ. Microbiol. 78(22):8112-8121.
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