EDUCATION
- B.S. Chemical Engineering, Massachusetts Institute of Technology
- B.S. Biology, Massachusetts Institute of Technology
- Minors in Biomedical Engineering and Film Studies
RESEARCH Project
Study differentiation of megakaryocytic cells (Mks; precursors to platelets), particularly mechanisms of how nicotinamide (vitamin B3) increases size and platelet-producing potential or primary human Mks.
Use a factorial design approach to strategically enhance the plate-producing capacity from a small population of hematopoietic stem and progenitor cells.
Determine the clinical significance of nicotinamide by observing its effect when applied to hematopoietic stem and progenitor cells isolated from patients diagnosed with myelodysplastic syndromes.
ADVISOR
- E. Terry Papoutsakis, Delaware Biotechnology Institute
- William M. Miller, Northwestern University
SELECTED PUBLICATIONS
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Giammona, L., Panuganti, S., Kemper, J., Papoutsakis, E.T., Miller, W.M., "Nicotinamide increases the ploidy of human megakaryocytes derived from CD34+ cells primarily due to SIRT inhibition." J Biol Chem, submitted.
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Kosto, K.B., Panuganti, S., and Deen, W.M, "Equilibrium partitioning of Ficoll in composite hydrogels." J Colloid Interface Sci, 277, 404-9 (2004).
RESEARCH SUMMARY KEYWORDS
- Hematopoiesis
- Megakaryocytes
- Nicotinamide
- SIRT
- Granulocytes
- Erythrocytes
- Factorial design
- Platelets
