EDUCATION
- Ph.D. - 2007 Bioinformatics, University of Michigan
- M.S. - 2001 Biotechnology, Southern Yangtze University, China
- B.E. - 1998 Biomedical Engineering, Southeast University, China
RESEARCH
Develop new computational and experimental methods to study non-coding RNAs in prokaryotes. Prokaryotic non-coding RNA (ncRNA) plays important roles in bacteria’s response to environment. Recent studies have shown their number far beyond previously expected. However, new convenient and efficient computational methods are urgently needed by the community to identify large number of novel ncRNAs. Particularly, the ncRNAs in clostridia is being studied in my research to identify the ncRNAs that are involved in clostridial solvent generation and human pathogenesis. My other research involves analyzing of microarray and next-generation sequencing data to study the genetic networks in clostridia and eukaryotic cells.
ADVISOR
Prof. Eleftherios T. Papoutsakis
SELECTED PUBLICATIONS
- Chen Y, Lin G, Huo JS, Barney D, Wang ZN, Livshiz T, States DJ, Qin ZS, Schwartz J. Computational and Functional Analysis of Growth Hormone (GH)-Regulated Genes Identifies the Transcriptional Repressor B-Cell Lymphoma 6 (Bc16) as a Participant in GH-Regulated Transcription. Endocrinology, 2009:150(8)
- Chen, Y., Blackwell, T.W., Chen, J., Gao, J., Lee, A.W., States, D.J. "Integration of Genome and Chromatin Structure with Gene Expression Profiles to Predict c-MYC Recognition Site Binding and Function", PLoS Computational Biology, 3: 602-615 (2007).
- Chen, J., Blackwell, T.W., Fermin, D., Menon, R., Chen, Y., Gao, J., Lee, A.W., States, D.J., "Evolutionarily Conserved Gene Expression Response Profiles across Mammalian Tissues", OMICS: A Journal of Integrative Biology, 11: 96-122 (2007).
- Lv, C., Tang, Y., Wang, L., Ji, W., Chen, Y., Yang, S., Wang, W., "Bioconversion of Yolk Cholesterol by Extracellular Cholesterol Oxidase from Brevibacterium sp.", Food Chemistry, 77: 457-463 (2002).
- Ji, W., Chen, Y., Zhang, H., Wang, W., Purification of Cholesterol Oxidase by Affinity Chromatography, (Chinese) Biotechnology,10: 16-19 (2000)
RESEARCH SUMMARY KEYWORDS
- Bioinformatics
- Computational Biology
- Systems Biology
