36. Cherry, R.S. and Papoutsakis, E.T., "Physical mechanisms of cell damage in microcarrier cell culture bioreactors", Biotechnol. Bioeng. 32: 1001-1014 (1988). (Download PDF)
38. Petersen, J.F., McIntire, L.V. and Papoutsakis, E.T., "Shear sensitivity of cultured hybridoma cells (CRL-8018) depends on mode of growth, culture age and metabolite concentration", J. Biotechnol. 7: 229-246 (1988).(Download PDF)
44. Cherry, R.S. and Papoutsakis, E.T., "Modeling of contact-inhibited animal cell growth on flat surfaces and spheres", Biotechnol. Bioeng. 33: 300-305 (1989). (Download PDF)
47. Cherry, R.S. and Papoutsakis, E.T., "Growth and death rates of bovine embryonic kidney cells in turbulent microcarrier bioreactors", Bioproc. Eng. 4: 81-89 (1989).(Download PDF)
50. Papoutsakis, E.T. and Kunas, K.T. "Hydrodynamic effects on cultured hybridoma cells CRL 8018 in an agitated bioreactor", in Adv. in Animal Cell Biology and Technology for Bioprocesses. (R. E. Spier et al., eds.). Butterworths. pp. 203-208 (1989).
54. Kunas, K.T., and Papoutsakis, E.T., "The protective effect of serum against hydrodynamic damage of hybridoma cells in agitated and surface aerated bioreactors", J. Biotechnol. 15: 57-70 (1990).(Download PDF)
55. Kunas, K.T., and Papoutsakis, E.T., "Increasing serum concentrations decrease cells death and allow growth of hybridoma cells at higher agitation rates", Biotechnol. Lett. 11: 525-530 (1989). (Download PDF)
56. Cherry, R.S. and Papoutsakis, E.T., "Understanding and controlling injury of animal cells in bioreactors", in Animal Cell Biotechnology (R.E. Spier and J.B. Griffiths, eds.), Vol. 4. Academic Press. Chp. 3: pp. 72-121 (1990).
57. Kunas, K.T., and Papoutsakis E.T., "Damage mechanisms of suspended animal cells in agitated bioreactors with and without bubble entrainment", Biotechnol. Bioeng. 36: 476-483 (1990).(Download PDF)
59. Petersen, J.F., McIntire, L.V. and Papoutsakis, E.T., "Shear sensitivity of freely suspended animal cells in batch, fedbatch, and continuous cultures", Biotechnol. Progr. 6: 114-120 (1990).
62. Papoutsakis, E.T., Petersen, J.F. and McIntire, L.V., "Cytoskeletal microfilament network and energy metabolism affect ability of animal cells to resist shear injury", in Production of Biologicals From Animal Cells In Culture (Proc. of the 10th ESACT Meeting, Avignon, France, May 1990) (Spier, R.E., Griffiths J. B., and Meigner, B., eds.). Butterworths, England. pp. 229-234 (1991).
63. Michaels, J. D., Petersen, J.F., McIntire, L.V. and Papoutsakis, E.T., "Protection mechanisms of freely suspended animal cells (CRL 8018) from fluid-mechanical injury. Viscometric and bioreactor studies using serum, Pluronic F68 and polyethylene glycol", Biotechnol. Bioeng. 38: 169-180 (1991).(Download PDF)
64. Michaels, J. D. and Papoutsakis, E.T., "Polyvinyl alcohol and polyethylene glycol as protectants against fluid-mechanical injury of freely suspended animal cells (CRL 8018)", J. Biotechnol. 19: 241-258 (1991). (Download PDF)
65. Lakhotia, S. and Papoutsakis, E.T., "Agitation induced cell injury in microcarrier cultures. The protective effect of viscosity is agitation-intensity dependent: Experiments and theory", Biotechnol. Bioeng. 39: 95-107 (1992). (Download PDF)
66. Papoutsakis, E.T., "Fluid-mechanical damage of animal cells in bioreactors (A review)", Trends in Biotechnol. 9: 427-437 (1991). (Download PDF)
67. Papoutsakis, E.T., "Media additives for protecting animal cells against agitation and aeration damage in bioreactors (A review)", Trends in Biotechnol. 9: 316-324 (1991). (Download PDF)
71. O'Connor, K.C. and Papoutsakis, E.T., "Agitation effects on microcarrier and suspension CHO cells", Biotechnol. Techn. 6: 323-328 (1992). (Download PDF)
73. Lakhotia, S., Bauer, K.D. and Papoutsakis, E.T., "Damaging agitation intensities increase DNA synthesis rate and alter cell cycle phase distributions of CHO cells", Biotechnol. Bioeng. 40: 978-990 (1992). (Download PDF)
74. Michaels, J.D., Kunas K.T. and Papoutsakis, E.T., "Fluid-mechanical Damage of freely-suspended cells in agitated bioreactors: Effects of dextran, derivatized celluloses and polyvinyl alcohol", Chem. Eng. Communic. 118: 341-360 (1992).
78. Borys, M.C. and Papoutsakis, E.T., "Formation of bridges, and large cellular clumps in CHO-cell microcarrier cultures: Effects of agitation, dimethyl sulfoxide and calf serum", Cytotechnol. 8: 237-248 (1992). (Download PDF)
82. Lakhotia, S., Bauer, K.D. and Papoutsakis, E.T., "Fluid-mechanical forces in agitated bioreactors reduce the CD13 and CD33 surface content of HL60 cells", Biotechnol. Bioeng. 41: 868-877 (1993). (Download PDF)
83. Borys, M.C., Linzer, D.I.H., and Papoutsakis, E.T., "Culture pH affects expression rates and glycosylation of recombinant mouse placental lactogen proteins by Chinese Hamster Ovary (CHO) cells", Bio/Technol. 11: 720-724 (1993). (Download PDF)
85. Papoutsakis, E.T. and Michaels, J.D., "Physical forces in mammalian cell bioreactors", in Physical Forces and the Mammalian Cells (J. Frangos, ed.). Academic Press, New York. Chp. 10: pp. 291-345 (1993).
87. Borys, M.C. and Papoutsakis, E.T., "‘Oxygenation', Module 8.D:1 of Part 8D: Biochemistry of Cells in Culture. Environmental Factors", in Protocols in Cell and Tissue Culture (J. B. Griffiths, Doyle, A., and Newell, D. G., eds.). Wiley, Chichester, UK. pp. 8D1.1-8D.1.13 (1993).
88. Borys, M.C. and Papoutsakis, E.T., "‘Mixing', Module 8.D:2 of Part 8D: Biochemistry of Cells in Culture. Environmental Factors", in Protocols in Cell and Tissue Culture (J. B. Griffiths, Doyle, A., and Newell, D.G., eds.), Wiley, Chichester, UK. pp. 8D:2.1-8D.2.8 (1993).
89. Papoutsakis, E.T., "‘Mechanical Protection, Module 8.D:3 of Part 8D: Biochemistry of Cells in Culture. Environmental Factors", in Protocols in Cell and Tissue Culture (J. B. Griffiths, Doyle, A., and Newell, D.G., eds.), Wiley, Chichester, UK. pp. 8D:3.1-8D.3.8 (1993).
97. Michaels, J.D., Wasan, D. and Papoutsakis, E.T., "Dynamic interfacial tension and rheological properties of cell culture media with shear protectants", in Animal Cell Technology: Products of Today, Prospects for Tomorrow (R. E. Spier, J. B. Griffiths, W. Berthold, eds.), Butterworth-Heinemann. pp. 389-391 (1994).
98. Borys, M.C., Linzer, D.I.H. and Papoutsakis, E.T., "Culture pH and ammonia affect expression rates and glycosylation of recombinant mouse placental lactogen proteins by CHO cells", in Animal Cell Technology: Products of Today, Prospects for Tomorrow (R. E. Spier, J. B. Griffiths, W. Berthold, eds.), Butterworth-Heinemann. pp. 658-660 (1994).
99. Borys, M.C., Linzer, D.I.H. and Papoutsakis, E.T., "Ammonia affects the glycosylation patterns of recombinant mouse placental lactogen-1 (mPL-I) by Chinese Hamster Ovary (CHO) Cells", Biotechnol. Bioeng. 43: 505-514 (1994). (Download PDF)
105. Michaels, J.D., Nowak, J.E., Mallik, A.K., Koczo, K., Wasan, D.T., and Papoutsakis, E. T., "Analysis of cell-to-bubble attachment in sparged bioreactors in the presence of cell protecting additives against shear", Biotechnol. Bioeng. 47: 407-419 (1995).(Download PDF)
106. Michaels, J. D., Nowak, J.E., Mallik, A.K., Koczo, K., Wasan, D.T., and Papoutsakis, E.T., "Interfacial properties of cell culture media with cell protecting additives against shear", Biotechnol. Bioeng. 47: 420-430 (1995).(Download PDF)
112. Michaels, J.D., Mallik, A.K., and Papoutsakis, E.T., "Sparging and agitation induced injury of cultured animal cells: Do bubble coalescence and breakup in the bulk liquid injure cells?", Biotechnol. Bioeng. 51: 399-409 (1996).
128. McDowell, C. L., and Papoutsakis, E T. "Decreasing extracellular pH increases CD13 receptor surface content and alters the metabolism of HL60 cells cultured in stirred tank reactors"", Biotechnol. Progr., 14: 567-572 (1998).(Download PDF)
129. McDowell, C. L., and Papoutsakis, E T. "Increased agitation intensity increases CD13 receptor surface content and mRNA levels, and alters the metabolism of HL60 cells cultured in a stirred tank bioreactor", Biotechnol. Bioeng. 60: 239-250 (1998).(Download PDF)
130. McDowell, C. L., Carver R., T., and Papoutsakis, E T. "Effects of Methocel A15LV, polyethylene glycol, and polivinyl alcohol on CD13 and CD33 receptor surface content and metabolism of HL60 cells cultured in stirred tank bioreactors", Biotechnol. Bioeng. 60: 251-258 (1998).(Download PDF)
131. McDowell, C. L., and Papoutsakis, E T. "Serum increases the CD13 receptor expression, reduces the transduction of fluid-mechanical forces, and alters the metabolism of HL60 cells cultured in agitated bioreactors", Biotechnol. Bioeng. 60: 259-268 (1998).(Download PDF)
149. McDowell, C. L., Borys,. M.C. and Papoutsakis, E T. "Animal cell culture: Physicochemical effects of pH", The Encyclopedia of Cell Technology (R. E. Spier, Ed.). Wiley, New York. pp. 63-70 (2000).
150. Carswell, K. S., and Papoutsakis, E. T. "Culture of human T-cells in stirred bioreactors for cellular immunotherapy applications: shear, proliferation, and the IL-2 receptor", Biotechnol. Bioeng. 68: 328-338 (2000).(Download PDF)
151. Carswell, K. S., Weiss, J. W. and Papoutsakis, E. T. "Low oxygen tension enhances the stimulation and proliferation of human T lymphocytes", Cytotherapy 2: 25-37 (2000).(Download PDF)
161. Haddad, H, Carswell, K. S., and Papoutsakis, E. T. "Ex vivo expansion of Human T lymphocytes", in Methods in Tissue Engineering (A. Atala & R. Lanza, Eds.), Academic Press, San Diego. Chapter 41: pp. 487-502 (2002).
177. Haddad-Adams, H., Windgassen, D., Ramsborg C. G., Paredes, C., and Papoutsakis, E. T. "Molecular understanding of oxygen-tension and patient-variability effects on Ex vivo expanded T-cells", Biotechnol. Bioeng. 87: 437-450 (2004).(Download PDF)
180. Ramsborg CG, D. Windgassen, C. J. Paredes and E. T. Papoutsakis, "Molecular insights into the pleiotropic effects of plasma on Ex vivo expanded T-cells using DNA-microarray analysis", Exp. Hematol. 32: 970-990 (2004).(Download PDF)