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Metabolic Flux Analysis: Theory and Experiments

12. Papoutsakis, E.T., "A Useful equation for fermentations of butyric-acid bacteria", Biotechnol. Lett. 5: 253-258 (1983).(Download PDF)

14. Papoutsakis, E.T., "A useful equation for fermentations of butyric-acid bacteria. Scenarios for controls of solvent production", in The Acetone-Butanol Fermentation and Related Topics, J.D. Bu'Lock and A.J. Bu'Lock, Eds. (Science and Technology Letters, London, 1983), Fermentation Research I, pp. 121-128.

15. Papoutsakis, E.T., "Equations and calculations for fermentations of butyric acid bacteria", Biotechnol. Bioeng. 26: 174-187 (1984).(Download PDF)

16. Papoutsakis, E.T. and Meyer, C.L., "Equations and calculations of product yields and preferred pathways for butanediol and mixed-acid fermentations", Biotechnol. Bioeng. 27: 50-66 (1985). (Download PDF)

17. Papoutsakis, E.T. and Meyer, C.L., "Fermentation equations for propionic- acid bacteria and for production of assorted oxychemicals from various sugars", Biotechnol. Bioeng. 27: 67-80 (1985). (Download PDF)

18. Chu, I-M. and Papoutsakis, E.T., "Carbon oxidation and incorporation patterns in batch cultures of Methylomonas L3" Biotechnol. Lett. 7, 15-20 (1985). (Download PDF)

22. Chu, I-M., Bussineau, C.M. and Papoutsakis, E.T., "Direct measurement of carbon-substrate oxidation and incorporation patterns in RuMP-Type methylotrophs. Chemostatic cultures of Methylomonas L3", Biotechnol. Bioeng. 27: 1623-1633 (1985).(Download PDF)

27. Bussineau, C.M. and Papoutsakis, E.T., "Intracellular reaction rates, enzyme activities and biomass yields in Methylomonas L3: Growth rate and substrate-composition effects", Appl. Microbiol. Biotechnol. 24: 435-442 (1986).(Download PDF)

30. Bussineau, C.M., Keuer, T.A., Chu, I-M. and Papoutsakis, E.T., "Effect of growth conditions on enzyme activities, intracellular kinetics and biomass yields of a new RuMP-Type methylotroph (T15)", Appl. Microbiol. Biotechnol. 26: 61-69 (1987). (Download PDF)

34. Meyer, C.L. and Papoutsakis, E.T., "Detailed stoichiometry and process analysis" In: Handbook on Anaerobic Fermentations (L.E. Erickson, D.Y.C. Fung, eds.) Chp. 4, pp. 83-118, Marcel Dekker, N.Y. (1988).

35. San, K-Y., Papoutsakis, E.T. and Stephanopoulos, G.N., "Measurement, data analysis, and control", pp. 441-462, Chp. 14 in Handbook on Anaerobic Fermentations (L.E. Erickson, D.Y.C. Fung, eds) Marcel Dekker, N.Y. (1988).

138. Desai, R., Nielsen, L. K., and Papoutsakis, E. T. "Stoichiometric modeling of Clostridium acetobutylicum fermentations with nonlinear constraints", J. Biotechnol. 71: 191-205 (1999). (Download PDF)

142. Papoutsakis, E. T., and Bennett, G. N. "Metabolic Engineering of Clostridium acetobutylicum", pp. 253-279, Chapter 11 in Metabolic Engineering (S.Y. Lee and E. T. Papoutsakis, Eds), Marcel Dekker, N.Y. (1999).

146. Desai, R. P., Harris, L. M., Welker, N. E., Papoutsakis, E. T. "Metabolic flux analysis elucidates the importance of the acid-formation pathway in regulating solvent production by Clostridium acetobutylicum", Metabolic Eng. 1: 206-213 (1999). (Download PDF)

147. Harris, L. M., Desai, R. P., Welker, N. E., Papoutsakis, E. T. "Characterization of recombinant strains of the Clostridium acetobutylicum butyrate kinase inactivation mutant: need for new phenomenological models for solventogenesis and butanol inhibition?", Biotechnol. Bioeng. 67: 1-11 (2000). (Download PDF)

159. L. M. Harris, L. Blank, R. P. Desai , N. E. Welker, and E. T. Papoutsakis "Fermentation characterization and flux analysis of  recombinant strains of Clostridium acetobutylicum with an inactivated solR gene" J. Ind. Microbiol. Biotechnol. 27: 322-328 (2001). (Download PDF)

207. Senger, R. S. and E. T. Papoutsakis. Genome-Scale Model for Clostridium acetobutylicum. Part 1. Reverse engineering to resolve network gaps, pathway discovery, and extrapolation to other clostridia. Biotechnol. Bioeng. Biotechnol. Bioeng. 101: 1036-1052 (2008)(Download PDF)

208. Senger, R. S. and E. T. Papoutsakis. Genome-Scale Model for Clostridium acetobutylicum. Part 2: Development of Specific Proton Flux States and Numerically-Determined Sub-Spaces. Biotechnol. Bioeng. Biotechnol. Bioeng. 101: 1053-1071 (2008)(Download PDF)