72. Koller, M.R., Bender, J.G., Miller, W.M. and Papoutsakis, E.T., "Effects of synergistic cytokine combinations, low oxygen, and irradiated stroma on the expansion of human cord blood progenitors", Blood. 80: 403-411 (1992).(Download PDF)

77. Koller, M.R., Bender, J.G., Papoutsakis, E.T. and Miller, W.M., "Beneficial effects of reduced oxygen tension and perfusion in long-term hematopoietic cultures", Ann. N.Y. Acad. Sci. 665: 105-116 (1992).

80. Koller, M.R., Bender, J.G., Miller, W.M. and Papoutsakis, E.T., "Expansion of primitive human hematopoietic progenitors in a perfusion bioreactor system with IL-3, IL-6 and stem-cell factor", Bio/Technol. 11: 358-363 (1993).

100. Sandstrom, C.E., Miller, W.M. and Papoutsakis, E T., "Review: serum-free media for cultures of primitive and mature hematopoietic cells", Biotechnol. Bioeng. 43: 706-733 (1994). (Download PDF)

102. Koller, M.R. and Papoutsakis, E.T., "Cell adhesion in animal cell culture: physiological and fluid-mechanical implications", Chapter in "Cell Adhesion: Fundamentals and Biotechnological Applications" (M. Hjortso, J. Roos, eds), Bioprocess Technology Series, No. 20. Marcel Dekker, New York. 20: pp. 61-110 (1995).

107. Sandstrom, C.E., Bender, J.G., Papoutsakis, E.T., and Miller, W.M., "Effects of CD34+ cell selection and perfusion on Ex vivo expansion of peripheral blood mononuclear cells", Blood. 86: 958-970 (1995).(Download PDF)

108. Papoutsakis, E.T., McAdams, T.A., Sandstrom, C.E., Miller, W.M., and Bender, J.G. "Ex vivo Expansion of Primitive Hematopoietic Cells for Cellular Therapies: An Overview", Cytotechnology. 18: 133-146 (1995).(Download PDF)

109. Sandstrom, C.E., Bender, J.G., Miller, W.M., and Papoutsakis, E.T. "Development of novel perfusion chamber to retain nonadherenT-cells and its use for comparison of human "mobilized" peripheral-blood cell cultures with and without irradiated bone marrow stroma", Biotechnol. Bioeng. 50: 493-504 (1996).(Download PDF)

110. Collins, P.C, Papoutsakis, E. T., & Miller, W.M. "Ex-vivo systems for hematopoietic cell therapies", Current Opinion in Biotechnology. 7: 223-230 (1996).

113. McAdams, T.A., Miller, W.M., and Papoutsakis, E.T., "Hematopoietic cell culture therapies: I. Cell culture considerations", Trends in Biotechnol. 14: 341-349 (September 1996).

114. McAdams, T.A., Winter, J. A., Miller, W.M., and Papoutsakis, E.T., "Hematopoietic cell culture therapies: II. Clinical aspects", Trends in Biotechnol. 14: 388-396 (October 1996).

116. Sandstrom, C.E., Collins, P.C., McAdams, T.A., Bender, J.G., Papoutsakis, E.T., and Miller, W.M., "Comparison of serum-deprived media for the Ex vivo expansion of hematopoietic progenitor cells from cord blood and peripheral blood mononuclear cells", J. Hematotherapy. 5: 461-473 (1996).

117. LaIauppa, J.A., Papoutsakis, E.T., and Miller, W.M. "Evaluation of cytokines for the expansion of megakaryocyte and granulocyte lineages", Stem Cells. 15: 198-206 (1997).(Download PDF)

118. LaIuppa, J.A., Papoutsakis, E.T., and Miller, W.M., "Ex vivo expansion of hematopoietic stem and progenitor cells for transplantation", in Blood Stem Cell Transplantation (J. Winter, Editor), Kluwer, New York. Chp. 8: pp.159-186 (1997).

119. McAdams, T.A., Miller, W.M., and Papoutsakis, E.T. "Effects of culture pH on the expansion and differentiation of hematopoietic progenitors from peripheral and cord blood", Br. J. Haematol. 97: 889-895 (1997).

120. Collins, P. C., Wong, C-K., Papoutsakis, E. T., and Miller, W. M., "Real time method for determining the colony-forming cell content of human hematopoietic cell cultures", Biotechnol. Bioeng. 55: 693-700 (1997).(Download PDF)

121. LaIauppa, J.A., McAdams, T.A., Papoutsakis, E.T., and Miller, W.M. "Culture materials affect Ex vivo expansion of hematopoietic progenitor cells", J. Biomed. Mat. Res. 36: 347-359 (1997).(Download PDF)

124. Collins, P. C., Miller, W. M., and Papoutsakis, E. T., "Stirred culture of peripheral and cord-blood hematopoietic cells offers advantages over traditional static systems for clinically relevant applications", Biotechnol. Bioeng. 59: 534-543 (1998).(Download PDF)

125. Collins, P. C., Nielsen, L. K., Patel, S. D., Papoutsakis, E. T., and Miller, W. M., "Characterization of hematopoietic cell expansion, oxygen uptake and glycolysis in a controlled, stirred-tank bioreactor system", Biotechnol. Progr. 14: 466-472 (1998).(Download PDF)

126. LaIauppa, J.A., Papoutsakis, E.T., and Miller, W.M. "Oxygen tension alters the effects of cytokines on the megakaryocyte, erythrocyte and granulocyte lineages", Exp. Hematol. 26: 835-843 (1998).

127. Nielsen, L. K., Papoutsakis, E. T., and Miller, W. M., "Modeling Ex vivo hematopoiesis using chemical engineering metaphors", Chem. Eng. Sci. 53: 1913-1925 (1998).(Download PDF)

132. Collins, P.C., Patel, S.D., Miller, W. M., and Papoutsakis, E. T. "Initiation, maintenance, and quantification of human hematopoietic cell cultures", in Methods in Molecular Medicine, Vol.18: Tissue Engineering Methods (J. R. Morgan, M. L. Yarmush, Eds), Human Press, Totowa, NJ. Chp. 22: pp. 271-292 (1999).

133. Horner, M, Miller, W.M., Ottino, J.M., and Papoutsakis, E.T., "Transport in a grooved perfusion flat-bed bioreactor for cell therapy applications", Biotechnol. Progr. 14: 689-699 (1998).(Download PDF)

134. McAdams, T.A., Miller, W.M., and Papoutsakis, E.T., "pH is a potent modulator of erythroid differentiation", Br. J. Haematol. 103: 317-325 (1998).

137. Nielsen, L. K., Bender, J. G., Miller, W.M., and Papoutsakis, E. T., "Population balance model of in vivo neutrophil formation following bone marrow rescue therapy", Cytotechnology. 28 (1/3): 157-162 (1998).(Download PDF)

139. Mostafa, S. S, Hevehan, D. L., McAdams, T.A., Papoutsakis, E. T. and Miller, W. M., "Hematopoietic cells for cellular and gene therapy: I. Basic assay techniques", in Animal Cell Biotechnology: Methods and Protocols (N. Jenkins, Ed.), Humana Press. Chapter 17: pp. 211-227 (1999).(Download PDF)

140. McAdams, T.A., Papoutsakis, E. T. and Miller, W. M., "Hematopoietic cells for cellular and gene therapy: II. Expansion Protocols", in Animal Cell Biotechnology: Methods and Protocols (N. Jenkins, Ed.), Human Press. Chapter 18: pp. 229-238 (1999).(Download PDF)

141. Collins, P. C., Papoutsakis, E. T., Patel, S. and Miller, W. M., "Nuclei size distribution as a predictor of hematopoietic cell proliferation", Cytotherapy. 1: 99-110 (1999).

144. Guo, M. H., Miller, W. M., Papoutsakis, E. T., Patel, S., James, C., Goolsby, C., and Winter J. N., "Ex vivo expansion of CFU-GM and BFU-E in unselected peripheral blood mononuclear cell cultures with Flt3L in enhanced by autologous plasma", Cytotherapy. 1: 183-194 (1999).

148. Hevehan, D. L., Papoutsakis, E. T. & Miller W. M., "Physiologically significant effects of pH and oxygen tension on granulopoiesis", Exp. Hematol. 28: 267-275 (2000).(Download PDF)

152. Patel, S.D, Guo, R., Miller, W.M., Papoutsakis, E.T., Minster, N.I., Baum, C.M., and Winter, J.N., "Clinical-scale expansion of progenitor and post-progenitor cells using daniplestim, leridistim, progenipoietin, promegapoietin and autologous plasma", Cytotherapy. 2: 85-94 (2000).

153. Patel, S.D., Miller, W.M., Winter, J.N., and Papoutsakis E.T., "Cell density-dependent proliferation in frequently fed peripheral blood mononuclear cell cultures", Cytotherapy. 2: 267-280 (2000).

154. Hevehan, D., Miller, W.M., and Papoutsakis, E.T., "A dynamic model of Ex vivo granulocytic kinetics to examine the effects of pO2, pH and IL-3", Exp. Hematol. 28:1016-1028 (2000).(Download PDF)

155. Patel, S.D., Papoutsakis, E.T., Winter, J.N., and Miller, W.M., "The lactic acid issue revisited: novel feeding protocols to examine inhibition of cell proliferation and glucose metabolism in hematopoietic cell cultures," Biotechnol. Progr. 16: 885-892 (2000).(Download PDF)

156. Mostafa, S.S., Miller, W.M., and Papoutsakis, E.T., "Oxygen tension influences the differentiation, maturation and apoptosis of human megakaryocytes", Br. J. Haematol. 111: 879-889 (2000).

158. Yang, H., Papoutsakis, E.T., and Miller, W.M., "Model-based estimation of myeloid hematopoietic progenitor cells using metabolic activities", Biotechnol. Bioeng. 72: 144-155 (2001).(Download PDF)

160. Mostafa, S.S., Papoutsakis, E.T., and Miller, W.M., "Oxygen tension modulates the expression of cytokine receptors, transcription factors and lineage-specific markers in cultured human megakaryocytes", Exper. Hematol. 29: 873-883 (2001).(Download PDF)

163. Chow, D., Miller, W.M., and Papoutsakis, E.T., "Estimation of Oxygen Tension Distributions of the Bone Marrow Hematopoietic Compartment. I. Krogh's model", Biophysical J. 81: 675-684 (2001).

164. Chow, D., Miller, W.M., and Papoutsakis, E.T., "Estimation of oxygen tension distributions of the bone marrow hematopoietic compartment. II. Modified Kroghian models", Biophysical J. 81: 685-696 (2001).(Download PDF)

165. Hevehan, D. L., Miller, W.M., and Papoutsakis, E.T., "Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation", Blood. 99: 1627-1637 (2002).(Download PDF)

167. Yang, H., Miller, W.M., and Papoutsakis, E. T., "Higher pH promotes megakaryocytic maturation and apoptosis", Stem Cells. 20: 320-328 (2002).(Download PDF)

192. Lisa M. Giammona, L. M., P. G. Fuhrken, E. T. Papoutsakis, and W. M. Miller, "Nicotinamide (vitamin B3) increases the polyploidisation and proplatelet formation of cultured primary human megakaryocytes" Brit. J. of Haematol. 135, 554-566 (2006).

193. Fuhrken, P.G., C. Chen; W. M. Miller, & E. T. Papoutsakis. Comparative, genome-scale transcriptional analysis of CHRF-288-11 and primary human megakaryocytic cell cultures provides novel insights into lineage-specific differentiation. Exp. Hematology, 35: 476-489 (2007).

194. Dipankar R, Y. Terao, P. G. Fuhrken, Z-Q. Ma, F. J. DeMayo, K. Christov, N. A. Heerema, R. Franks, S. Y. Tsai, E. T. Papoutsakis and H. Kiyokawa. "Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instability", Cancer Res., 67: 984-991 (2007).(Download PDF)

200. Chen, C, Fuhrken, P.G., Huang L.T, Paredes, C. J., Miller, W. M. & E. T. Papoutsakis. A systems-biology analysis of isogenic megakaryocytic and granulocytic cultures identifies new molecular components of megakaryocytic apoptosis. BMC Genomics 8: 384 (doi:10.1186/1471-2164-8-384) (2007).(Download PDF)

201. Huang, L.T., Paredes, C.J., Papoutsakis, E.T., Miller W.M., Gene-expression analysis illuminates the transcriptional programs underlying the functional activity of ex-vivo expanded granulocytes. Physiol Genomics. 31: 114-125 (2007).(Download PDF)

202. Wang, H., Lu, Y., Huang, W., Papoutsakis, E.T., Fuhrken, P., Eklund, E.A., HoxA10 activates transcription of the gene encoding mitogen-activated protein kinase phosphatase 2 (Mkp2) in myeloid cells. J Biol. Chem. 282: 16164-76. (2007).(Download PDF)

205. Fuhrken, P. G., C. Chen, P. A. Apostolidis, M. Wang, W. M. Miller, E. T. Papoutsakis. Gene-Ontology driven transcriptional analysis of CD34+-cell initiated megakaryocytic cultures identifies new transcriptional regulators of megakaryopoiesis. Physiol. Genomics. (2008) doi:10.1152/physiolgenomics.00127.2007.(Download PDF)

206. Sepúlveda D.E., B. A. Andrews, J. A. Asenjo, & E. T. Papoutsakis. Comparative transcriptional analysis of embryoid body versus two-dimensional differentiation of murine embryonic stem cells. Tissue Eng. Accepted (2008).(Download PDF)

210. Peter G. Fuhrken, Pani A. Apostolidis, Stephan Lindsey, William M. Miller, and Eleftherios T. Papoutsakis. Tumor suppressor protein p53 regulates megakaryocytic polyploidization and apoptosis. J. Biol. Chem., Apr 2008; doi:10.1074/jbc.M801923200.(Download PDF)

210. Peter G. Fuhrken, Pani A. Apostolidis, Stephan Lindsey, William M. Miller, and Eleftherios T. Papoutsakis Tumor suppressor protein p53 regulates megakaryocytic polyploidization and apoptosis. J. Biol. Chem., Apr 2008; doi:10.1074/jbc.M801923200. (Download PDF )